Miyoshi T, Nakamura K, Amioka N, Hatipoglu OF, Yonezawa T, Saito Y, Yoshida M, Akagi S, Ito H. LCZ696 ameliorates doxorubicin-induced cardiomyocyte toxicity in rats. Sci Rep. 12(1): 4930. (2022) doi: 10.1038/s41598-022-09094-z.

Yamano R, Miyazaki H, Nukina N. The diffuse distribution of Nav1.2 on mid-axonal regions is a marker for unmyelinated fibers in the central nervous system. Neurosci Res. 177:145-150. (2022) doi: 10.1016/j.neures.2021.11.005.

Nosho S, Ono M, Komori T, Mikai A, Tosa I, Ishibashi K, Tanaka Y, Kimura-Ono A, Hara ES, Oohashi T, Kuboki T. Preclinical bioequivalence study of E.coli-derived rhBMP-2/β-TCP and autogenous bone in a canine guided-bone regeneration model. J Prosthodont Res. 66(1):124-130. (2022) doi: 10.2186/jpr.JPR_D_20_00226.


Tanaka Y, Aung KT, Ono M, Mikai A, Dang AT, Hara ES, Tosa I, Ishibashi K, Ono-Kimura A, Nawachi K, Kuboki T, Oohashi T. Suppression of Bone Necrosis around Tooth Extraction Socket in a MRONJ-like Mouse Model by E-rhBMP-2 Containing Artificial Bone Graft Administration. Int J Mol Sci. 22(23):12823. (2021) doi: 10.3390/ijms222312823.

Mukai T, Akagi T, Hiramatsu Asano S, Tosa I, Ono M, Kittaka M, Ueki Y, Yahagi A, Iseki M, Oohashi T, Ishihara K, Morita Y. Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model. Oral Dis. 10.1111/odi.14073. (2021) doi: 10.1111/odi.14073.

Nojima K, Miyazaki H, Hori T, Vargova L, Oohashi T. Assessment of Possible Contributions of Hyaluronan and Proteoglycan Binding Link Protein 4 to Differential Perineuronal Net Formation at the Calyx of Held. Front Cell Dev Biol. 9:730550. (2021) doi: 10.3389/fcell.2021.730550. eCollection 2021.

Chun BY, Kim JH, Jung YK, Choi YS, Kim G, Yonezawa T, Suk K. Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis. Invest Ophthalmol Vis Sci. 62(9):8. doi: 10.1167/iovs.62.9.8.

Tang S, Yonezawa T, Maeda Y, Ono M, Maeba T, Miyoshi T, Momota R, Tomono Y, Oohashi T. Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation. PLoS One. 16(4):e0249909. (2021) doi: 10.1371/journal.pone.0249909. eCollection 2021.


Nosho S, Tosa I, Ono M, Hara ES, Ishibashi K, Mikai A, Tanaka Y, Kimura-Ono A, Komori T, Maekawa K, Kuboki T, Oohashi T. Distinct Osteogenic Potentials of BMP-2 and FGF-2 in Extramedullary and Medullary Microenvironments. Int J Mol Sci. 21(21):7967. (2020) doi: 10.3390/ijms21217967

Mikai A, Ono M, Tosa I, Nguyen HTT, Hara ES, Nosho S, Kimura-Ono A, Nawachi K, Takarada T, Kuboki T, Oohashi T. BMP-2/β-TCP Local Delivery for Bone Regeneration in MRONJ-Like Mouse Model. Int J Mol Sci. 21(19):7028. (2020) doi: 10.3390/ijms21197028.

Hatipoglu OF, Miyoshi T, Yonezawa T, Kondo M, Amioka N, Yoshida M, Akagi S, Nakamura K, Hirohata S, Ito H. Deficiency of CD44 prevents thoracic aortic dissection in a murine model. Sci Rep. 10(1):6869. (2020) doi: 10.1038/s41598-020-63824-9.

Sucha P, Chmelova M, Kamenicka M, Bochin M, Oohashi T, Vargova L. The effect of Hapln4 link protein deficiency on extracellular space diffusion parameters and perineuronal nets in the auditory system during aging. Neurochem Res. 45(1):68-82 (2020)


Bekku Y, Oohashi T. Under the ECM Dome: The Physiological Role of the Perinodal Extracellular Matrix as an Ion Diffusion Barrier. Adv Exp Med Biol. 1190:107-122 (2019) doi: 10.1007/978-981-32-9636-7_8. Review.

Nomura Y, Hara ES, Yoshioka Y, Nguyen HT, Nosho S, Komori T, Ishibashi K, Oohashi T, Ono M, Kuboki T. DNA Methylation-Based Regulation of Human Bone Marrow-Derived Mesenchymal Stem/Progenitor Cell Chondrogenic Differentiation. Cells Tissues Organs. 207(3-4):115-126.(2019) doi: 10.1159/000502885.

Nguyen HTT, Ono M, Hara ES, Komori T, Edamatsu M, Yonezawa T, Kimura-Ono A, Maekawa K, Kuboki T, Oohashi T. Type XVIII Collagen Modulates Keratohyalin Granule Formation and Keratinization in Oral Mucosa. Int J Mol Sci. 20(19):4739. (2019) doi: 10.3390/ijms20194739.

Yamada D, Kawabe K, Tosa I, Tsukamoto S, Nakazato R, Kou M, Fujikawa K, Nakamura S, Ono M, Oohashi T, Kaneko M, Go S, Hinoi E, Yoneda Y, Takarada T. Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system. Commun Biol. 2:346 (2019)

Ohtsuki T, Shinaoka A, Kumagishi-Shinaoka K, Asano K, Hatipoglu OF, Inagaki J, Takahashi K, Oohashi T, Nishida K, Naruse K, Hirohata S. Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. Exp Cell Res. 383(2):111556 (2019)

Tosa I, Yamada D, Yasumatsu M, Hinoi E, Ono M, Oohashi T, Kuboki T, Takarada T. Postnatal Runx2 deletion leads to low bone mass and adipocyte accumulation in mice bone tissues. Biochem Biophys Res Commun. 516(4):1229-1233 (2019)

Fawcett JW, Oohashi T, Pizzorusso T. The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function. Nat Rev Neurosci. 20(8):451-465 (2019)

Yonezawa T, Momota R, Iwano H, Zhao S, Hakozaki T, Soh C, Sawaki S, Toyama K, Oohashi T. Unripe peach (Prunus persica) extract ameliorates damage from UV irradiation and improved collagen XVIII expression in 3D skin model. J Cosmet Dermatol. 18(5):1507-1515 (2019) doi: 10.1111/jocd.12841.

Maeba T, Yonezawa T, Ono M, Tomono Y, Heljasvaara R, Pihlajaniemi T, Inagawa K, Oohashi T.  Collagen XVIII deposition in the basement membrane zone beneath the newly forming epidermis during wound healing in mice. Acta Med Okayama 73(2):135-146 (2019)

Hazehara-Kunitomo Y, Hara ES, Ono M, Aung KT, Komi K, Pham HT, Akiyama K, Okada M, Oohashi T, Matsumoto T, Kuboki T. Acidic Pre-Conditioning Enhances the Stem Cell Phenotype of Human Bone Marrow Stem/Progenitor Cells. Int J Mol Sci. 20(5): pii: E1097 (2019) doi: 10.3390/ijms20051097.

Nguyen HT, Ono M, Oida Y, Hara ES, Komori T, Akiyama K, Nguyen HTT, Aung KT, Pham HT, Takarada T, Matsuo K, Mizoguchi T, Oohashi T, Kuboki T. Bone marrow cells inhibit BMP-2-induced osteoblast activity in the marrow environment. J Bone Miner Res., 34(2):327-332 (2019) , doi: 10.1002/jbmr.3598.


Edamatsu M, Miyano R, Fujikawa A, Fujii F, Hori T, Sakaba T, Oohashi T. Hapln4/Bral2 is a selective regulator for formation and transmission of GABAergic synapses between Purkinje and deep cerebellar nuclei neurons. J Neurochem. 147: 748-763 (2018)

Ohtsuki T, Asano K, Inagaki J, Shinaoka A, Kumagishi-Shinaoka K, Cilek MZ, Hatipoglu OF, Oohashi T, Nishida K, Komatsubara I, Hirohata S. High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression. J Orthop Res. 36(12): 3247-3255 (2018) doi: 10.1002/jor.24126.

Komori T, Ono M, Hara ES, Ueda J, Nguyen HTT, Nguyen HT, Yonezawa T, Maeba T, Kimura-Ono A, Takarada T, Momota R, Maekawa K, Kuboki T, Oohashi T. Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium. Sci Rep. 8:2612 (2018)

Asano K, Edamatsu M, Hatipoglu O F, Cilek M Z, Inagaki J, Ohtsuki T, Oohashi T, Hirohata S. Host-produced ADAMTS4 inhibited early stage of tumor growth. Acta Med Okayama, 72(3):257-266 (2018)

Cicanic M, Edamatsu M, Bekku Y, Vorisek I, Oohashi T, Vargova L. A deficiency of the link protein Bral2 affects the size of the extracellular space in the thalamus of aged mice. J Neurosci Res. 96(2):313-327 (2018)

Ishikawa T, Nishida T, Ono M, Takarada T, Nguyen HT, Kurihara S, Furumatsu T, Murase Y, Takigawa M, Oohashi T, Kamioka H, Kubota S. Physiological role of urothelial cancer-associated one long noncoding RNA in human skeletogenic cell differentiation. J Cell Physiol. 233(6):4825-4840 (2018)

Ono M, Masaki A, Maeda A, Kilts TM, Hara ES, Komori T, Pham H, Kuboki T, Young MF. CCN4/WISP1 controls cutaneous wound healing by modulating proliferation, migration and ECM expression in dermal fibroblasts via α5β1 and TNFα. Matrix Biol. 17: 30400-6 (2018)

Yoshihara-Hirata C, Yamashiro K, Yamamoto T, Aoyagi H, Ideguchi H, Kawamura M, Suzuki R, Ono M, Wake H, Nishibori M, Takashiba S. Anti-HMGB1 neutralizing antibody attenuates periodontal inflammation and bone resorption in a murine periodontitis model. Infect Immun. Mar 12. pii: IAI.00111-18 (2018)

Morisawa A, Okui T, Shimo T, Ibaragi S, Okusha Y, Ono M, Nguyen TTH, Hassan NMM, Sasaki A. Ammonium tetrathiomolybdate enhances the antitumor effects of cetuximab via the suppression of osteoclastogenesis in head and neck squamous carcinoma. Int J Oncol. 52(3):989-999 (2018)


Asano K, Nelson CM, Nandadasa S, Aramaki-Hattori N, Lindner DJ, Alban T, Inagaki J, Ohtsuki T, Oohashi T, Apte SS, Hirohata S. Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis. Sci Rep. 7:17225 (2017)

Ono M, Oshima M, Ogawa M, Sonoyama W, Hara ES, Oida Y, Shinkawa S, Nakajima R, Mine A, Hayano S, Fukumoto S, Kasugai S, Yamaguchi A, Tsuji T, Kuboki T. Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model. Sci Rep. 7:44522 (2017)

Popelář J, Díaz Gómez M, Lindovský J, Rybalko N, Burianová J, Oohashi T, Syka J. The absence of brain-specific link protein Bral2 in perineuronal nets hampers auditory temporal resolution and neural adaptation in mice. Physiol Res. 66(5):867-880 (2017)

Sado Y, Inoue S, Tomono Y, Matsuyama M, Fukushima M, Oohashi T, Jogahara T, Oda S. Monoclonal Suncus Antibodies: Generation of Fusion Partners to Produce Suncus-Suncus Hybridomas. Acta Histochem. Cytochem. 50(2):71-84 (2017)

Matoba R, Morizane Y, Shiode Y, Hirano M, Doi S, Toshima S, Araki R, Hosogi M, Yonezawa T, Shiraga F. Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells. PLoS One. 12(7):e0181481 (2017)

Shiode Y, Morizane Y, Matoba R, Hirano M, Doi S, Toshima S, Araki R, Hosogi M, Takahashi K, Kanzaki Y, Yonezawa T, Shiraga F. A novel cell exclusion zone assay with a barrier made from room temperature vulcanizing silicone rubber. PLoS One. 12(12):e0190198 (2017)

Shiode Y, Morizane Y, Matoba R, Hirano M, Doi S, Toshima S, Takahashi K, Araki R, Kanzaki Y, Hosogi M, Yonezawa T, Yoshida A, Shiraga F. Invest Ophthalmol Vis Sci. 58(11):4847-4855 (2017)


Murata T, Katayama K, Oohashi T, Jahnukainen T, Yonezawa T, Sado Y, Ishikawa E, Nomura S, Tryggvason K, Ito M. COL4A6 is dispensable for autosomal recessive Alport syndrome. Sci Rep. 6:29450 (2016)

Hara E, Ono M, Yoshioka Y, Ueda J, Hazehara Y, Pham H, Matsumoto T, Kuboki T. Antagonistic effects of insulin and TGF-ß3 during chondrogenic differentiation of human BMSCs under minimal amount of factors. Cells Tissues Organs. 201(2): 88-96 (2016)

Faralli A, Dagna F, Albera A, Bekku Y, Oohashi T, Albera R, Rossi F, Carulli D.
Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse.
Brain Structure and Function. 221(6):3193-209 (2016)

Kimura K, Nakayama M, Naito I, Komiyama T, Ichimura K, Asano H, Tsukuda K, Ohtsuka A, Oohashi T, Miyoshi S, Ninomiya Y.
Human collagen XV is a prominent histopathological component of sinusoidal capillarization with the hepatocellular carcinogenesis.
Int J Clin Oncol.21(2):302-9 (2016)


Oohashi T, Edamatsu M, Bekku Y, Carulli D.
The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity. Exp Neurol. 274 (Pt B), 134-144 (2015) doi: 10.1016/j.expneurol.2015.09.010.

Yoshioka Y, Ono M, Maeda A, Kilts TM, Hara ES, Khattab H, Ueda J, Aoyama E, Oohashi T, Takigawa M, Young MF, and Kuboki T. CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-b3 function. Bone, 83, 162-170 (2015)

大橋俊孝 ことば「ランビエ絞輪とパラノード」「跳躍伝導」,生化学, 87巻5号,643. (2015)

大橋俊孝枝松緑別宮洋子 成熟脳のペリニューロナルECMの形成と機能について,生化学, 87巻3号,393-396 (2015)

大橋俊孝, 基底膜ツールキットとしての XV/XVIII型コラーゲン遺伝子の機能,岡山医学会雑誌, 第127巻,103-109 (2015)

Ishii H, Kamikawa S, Hirohata S, Mizutani A, Abe K, Seno M, Oohashi T, Ninomiya Y.
Eosinophil cationic protein shows survival effect on H9c2 cardiac myoblast cells with enhanced phosphorylation of ERK and Akt/GSK3β under oxidative stress.
Acta Med Okayama. 69(3):145-153 (2015)

Kawata K, Morishita K, Nakayama M, Yamada S, Kobayashi T, Furusawa Y, Arimoto-Kobayashi S, Oohashi T, Makishima M, Naitou H, Ishitsubo E, Tokiwa H, Tai A, Kakuta H.
RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects.
J Med Chem. 58(2): 912-926 (2015)

Maeda A, Ono M,  Holmbeck K, Li L, Kilts TM, Kram V, Noonan ML, Yoshioka Y, McNerny E, Tantillo M, Kohn D, Lyons KM, Robey PG, Young MF. WNT1 induced secreted protein-1 (WISP1): A novel regulator of bone turnover and Wnt signaling. Journal of Biological Chemistry, 290(22):14004-18 (2015)

Hara ES, Ono M, Pham HT, Sonoyama W, Kubota S, Takigawa M, Matsumoto T, Young MF, Olsen BR, Kuboki T. Fluocinolone Acetonide is a Potent Synergistic Factor of TGF-β3-Associated Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells for Articular Surface Regeneration. J Bone Miner Res. 30(9), 1585-96 (2015).

Ishimoto K, Hayano S, Yanagita T, Kurosaka H, Kawanabe N, Itoh S, Ono M, Kuboki T, Kamioka H, Yamashiro T. Topical application of lithium chloride on the pulp induces dentin regeneration. PLoS One. 26;10(3):e0121938 (2015).


Maehara A, Nishida K, Furutani M, Matsumoto E, Ohtsuka A, Ninomiya Y, Oohashi T.
Light and electron microscopic detection of inflammation-targeting liposomes encapsulating high-density colloidal gold in arthritic mice.
Inflamm Res. 63(2):139-147 (2014)

Demircan K, Topcu V, Takigawa T, Akyol S, Yonezawa T, Ozturk G, Ugurcu V, Hasgul R, Yigitoglu MR, Akyol O, McCulloch DR, Hirohata S.
ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.
Biomed Res Int. 2014:693746 (2014)

Inagaki J, Takahashi K, Ogawa H, Asano K, Faruk Hatipoglu O, Cilek MZ, Obika M, Ohtsuki T, Hofmann M, Kusachi S, Ninomiya Y, Hirohata S.
ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor.
Exp Cell Res. 323(2):263-275 (2014)

Miyoshi T, Nakamura K, Yoshida M, Miura D, Oe H, Akagi S, Sugiyama H, Akazawa K, Yonezawa T, Wada J, Ito H.
Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats.
Cardiovasc Diabetol. 3:43 (2014)

Abali O, Gokce EC, Cemil B, Erdogan B, Yonezawa T, Demircan K.
Early Induction of ADAMTS 1, -4, -5 and -9 in IL-Stimulated Mouse Astrocytes.
Turk Neurosurg. 24(4):519-24 (2014)

Mukai T, Ishida S, Ishikawa R, Yoshitaka T, Kittaka M, Gallant R, Lin YL, Rottapel R, Brotto M, Reichenberger EJ, Ueki Y.
SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.
J Bone Miner Res. 2014 Dec;29(12):2618-35 (2014)

Yoshitaka T, Mukai T, Kittaka M, Alford LM, Masrani S, Ishida S, Yamaguchi K, Yamada M, Mizuno N, Olsen BR, Reichenberger EJ, Ueki Y.
Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism.
Cell Rep. 8(6):1752-166 (2014)

〜2013 まで(抜粋)

Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN.
Three mechanisms assemble central nervous system nodes of Ranvier.
Neuron. 78(3):469-82 (2013)

Young TR, Bourke M, Zhou X, Oohashi T, Sawatari A, Fässler R, Leamey CA.
Ten-m2 is required for the generation of binocular visual circuits.
J Neurosci. 33(30):12490-12509 (2013)

Demircan K, Yonezawa T, Takigawa T, Topcu V, Erdogan S, Ucar F, Armutcu F, Yigitoglu MR, Ninomiya Y, Hirohata S.
ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse.
Neurosci Lett. 544: 25-30 (2013)

Momota R, Narasaki M, Komiyama T, Naito I, Ninomiya Y, Ohtsuka A.
Drosophila type XV/XVIII collagen mutants manifest integrin mediated mitochondrial dysfunction, which is improved by cyclosporin A and losartan.
Int J Biochem Cell Biol. 45(5):1003-1011 (2013)

Bekku Y, Saito M, Moser M, Fuchigami M, Maehara A, Nakayama M, Kusachi S, Ninomiya Y, Oohashi T. Bral2 is indispensable for the proper localization of brevican and the structural integrity of the perineuronal net in the brainstem and cerebellum.
J Comp Neurol. 520(8):1721-36 (2012)

Obika M, Ogawa H, Takahashi K, Li J, Hatipoglu OF, Cilek MZ, Miyoshi T, Inagaki J, Ohtsuki T, Kusachi S, Ninomiya Y, Hirohata S.
Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis.
Cancer Sci. 103(10):1889-1897 (2012)

Bekku Y, Vargová L, Goto Y, Vorísek I, Dmytrenko L, Narasaki M, Ohtsuka A, Fässler R, Ninomiya Y, Syková E, Oohashi T. Bral1: its role in diffusion barrier formation and conduction velocity in the CNS.
J Neurosci. 30(8):3113-3123 (2010)